Screening potential biomarkers associated with insulin resistance in high-fat diet-fed mice by integrating metagenomics and untargeted metabolomics
ABSTRACTInsulin resistance is the primary pathophysiological basis for metabolic syndrome and type 2 diabetes.Gut microbiota and microbiota-derived metabolites are pivotal in insulin resistance.However, identifying the specific microbes and key metabolites with causal roles is a challenging task, and the underlying mechanisms require further explor